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Constantly monitor the mini-map and teammates' HP-bars. With your "Reversal of Fortune" Ult you can really save your allies and urn a duel into a 1 vs. 2
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(Early Game) Muriel can solo defend a lane if everyone is busy, but always play defensive and never chase until a jungler or battle budy comes to help.
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Remember that if Muriel's Ult is cancelled prior to selecting a target then you will go to a full cooldown